The role of collagen type II with cartilage and height

What is collagen type II?

Collagen is the body’s main protein, found in muscles, bones, skin, blood vessels, the digestive system, and tendons. Collagen helps to keep the skin smooth and elastic, replacing dead skin cells. As for joints and tendons, collagen is the “glue” that connects the components together. There are 29 types of collagen, of which the most are collagen types I, II, III, VI.

Collagen type II is the main structural component of articular cartilage, accounting for 50% of cartilage protein and 85-90% of total collagen in articular cartilage. This is the type of collagen responsible for the strength and flexibility of cartilage. In addition, there is collagen type 10 in joints. Recent studies show that collagen type 10 is involved in the process of creating bones and cartilage.

Type II collagen is fibrous, woven together to create a network, attached to other proteins to create a flexible structure. Collagen type II is rich in amino acids such as: Arginine, Proline, Glycine, Glutamine. In addition, Collagen type II also has Chondroitin and Glucosamine.

The benefits of collagen type II

1. Reduce joint pain, autoimmune arthritis.
2. Improve immune system.
3. Skin care and beauty.
4. Increase digestion.
5. Increase joint mobility.
6. In nature, collagen type II is abundant in chicken breast cartilage.

What is type II hydrolyzed collagen?

Type II hydrolyzed collagen is a form of collagen obtained when collagen fibers are broken down into small collagen chains called “Collagen peptides” through the process of “hydrolysis”. This technology was invented and patented by a Japanese company. After hydrolysis, Collagen peptide loses its gelling ability and becomes soluble in cold water. This type of collagen has 10-20 times higher levels of amino acids, glycine, proline and hydroxyproline than normal proteins. Because it is hydrolyzed into smaller molecules, collagen peptides help the absorption process into the body optimally, bringing faster results than regular collagen.

Instead of providing amino acids that need to be broken down and then assembled into collagen, hydrolyzed collagen can effectively deliver small usable collagen peptides into our bodies. Clinical studies have shown that these collagen peptides are absorbed into the bloodstream, penetrate and remain in joint cartilage and activate collagen production in the skin.

The role of collagen type II with joint cartilage

The accumulation of hydrolyzed collagen in cartilage stimulates the production of type II collagen by chondrocytes. Since then, Collagen type II participates in the process of creating new cartilage. Several studies have shown that daily oral administration of Hydrolyzed Collagen increases bone density in rats.
Preliminary evidence suggests that collagen type II may help relieve osteoarthritis (OA) and rheumatoid arthritis (RA) pain. Some studies have found that a product containing collagen type II can provide short-term pain relief for patients with chronic arthritis. Collagen type II with chondroitin sulfate and glucosamine sulfate – both are great for joints and maintain the right pH levels.

In a randomized trial of 60 patients with severely active rheumatoid arthritis, patients receiving Collagen type II treatment for three months experienced a reduction in the number of swollen and painful joints. The patients taking the placebo did not experience any improvement. Four of the patients in the Collagen group had a reduction in their joint inflammation, and the patients taking Collagen had no apparent adverse effects.

Medically, osteoarthritis is recognized as a process of damage to joint cartilage. Specifically, damage to collagen fibers and the substrate present in joint cartilage. When articular cartilage is damaged, the inflammatory process takes place, a part of cartilage fragments and broken collagen fibers penetrate into the blood vessels, at this time the immune system is activated to proceed to clean up broken and broken collagen fibers under the influence of stress. Commander of T-Killer cells (cells that clean up damaged components in the body). At the same time, the immune system will inadvertently attack all the same collagen – including the healthy collagen in the joint cartilage. It is this “self-destruction” that pushes the cartilage degeneration process to take place faster and faster.

Collagen type II when taken into the body, 53% will be absorbed into the blood, becoming an important source of raw materials for the process of regeneration and nourishment of joint cartilage. The rest (47%) is not decomposed, but goes to the small intestine to interact with the quarantine agency, which is Peyer’s array, helping the body recognize Collagen as a “familiar”, reducing the activity of T-Killer cells. so as not to destroy the absorbed collagen. At the same time, it prevents the natural destruction of joint cartilage that is taking place, thereby helping to slow down the process of joint degeneration. The supply of Collagen type II to the body will act like “one arrow hits two targets”, both helping the body protect and regenerate joint cartilage from the new material Collagen type II and have an immunomodulatory effect. , slow down cartilage inflammation and prevent cartilage damage from spreading.

Collagen type II deficiency is associated with chondrodysplasias, often inherited, causing dwarfism and bone deformities.

The role of collagen type II with height

To understand how collagen type II plays a role in the natural way of increasing height , we need to know a little about bone growth .

Humans grow taller due to the elongation of the long bones (such as the femur, the bones of the lower leg) and the vertebrae. This process, called cartilaginous osteogenesis, takes place from the womb until the growth plates at the ends of the bone are fully ossified (usually ages 21-25). During this process, the cartilage near the bone body will absorb calcium, the cartilage cells die and create osteoblasts that will build bone cells.

Cartilage cells at the ends of bones will continuously proliferate, creating new cartilage to replace the part that has turned into bone and provide bone matrix (Collgen type 10 and fibronectin). To create new cartilage, the raw material is Collagen type II. If there is not enough Collagen type II, the process of bone formation will stop, this is chondrodysplasia, and the body cannot grow taller. The replacement of cartilage cells with bone cells requires mineralization – this is the extremely important role of calcium.

Dosage

Collagen type II can be safely used continuously for 24 weeks.
The appropriate dose of Type II Collagen depends on many factors such as the user’s age , health, and several other conditions (diet, allergies, etc.) dose from 500-4000 mg/day.

Side effects

Possible: Nausea, heartburn, diarrhea, constipation, somnolence, skin reactions and headache.
Pregnancy and breast-feeding: There isn’t enough reliable information about the safety of using Collagen type II if you are pregnant or breast-feeding. People who are allergic to meat or eggs should not use collagen type II.